Hi Riptorn, i have used spybot for a long time on both my machines. I do not use its tea timer (resident protection) I only use resident SD helper (browser protection). which i value as it has blocked me from a couple of links to blacklisted websites. I have no probs with it slowing down my browsers not even IE8, but some people have apparently this is a result of storing large amounts of cookies. otherwise i update once a week (updates are released every wednesday) reimmunise and run a manual scan on that day.
I to would recommend Malwarebytes free stand alone scanner as an essential tool (you would be amazed at what it can find)
As far as Resident scanners i find Avast & Defender lightwieght and sufficient, and then maybee once a week i do a manual scan with spybot and malwarebytes.
Just so you know if you are running Kaspersky it will not allow you to use spybot. I hope this is of some help in making a decision, all the best