McAfee is the first problem.
Both McAfee and Norton Antivirus are incompatible with Windows
Mail, and they would need to be uninstalled. Replace with a
compatible antivirus like the free version of Avast:
http://www.avast.com/eng/download-avast-home.html
After you do the above, if you still get a similar error message,
let me know if
a) you are using a laptop away from home, or
b) you are sending from home but using an SMTP server
other than the one supplied by your ISP.
Gary VanderMolen
"CnK" <CnK@discussions.microsoft.com> wrote in message news:163EB1FA-2AAF-4B0C-9134-1540A25E9C7D@microsoft.com...
> Hello,
>
> I have a new computer running Vista, whenever I send an emial using Windows
> Mail I get "550 not local host #$%%^.com, not a gateway" error from McAffee.