gdubu

I can't open any files on my computer. I get the following message

"Windows cannot access the specified device,path or file. You may not have
appropriate permissions to access the item."

Of course MSN Messenger works, which allows me to get to IE to add this
thread.

Clicking on the IE Icon or navigating to a file via windows explorer and
clicking on a file always comes up with this same error message.

Suggestions on how to solve this problem?