There is a lot of good stuff out there.
WinBubble can be used to "Tweak" things, but the average user had better stay clear of it as it will screw up your system (Like Tweak VI) unless you really know what you are doing and not think you do.
I have rescued many computers due to "User Error".
Research before downloading all kinds of useless and/or dangerous software.
Keep your computer free of spy-ware/ad-ware , update your anti-virus, and run some cleaner tools now and then.
Bells and whistles only slow down a unit and although they look nice, you are compromising performance for appearance.......

I have running a few good strong programs for protection however I have quite a few programs in my arsenal that I call upon randomly to screen , scan and confirm a clean safe system. These programs do not run on start-up and are only used when I do the weekly or b-weekly checks.
So far nothing on this new system and only two viruses were detected on my old XP system over 6 years....