WildEagle

All I do is run a TuneUp once a week, which does a defrag, cleans up files that are no longer needed, and does a full system scan for viruses. I also uninstalled the features from Vista, that I don't need or wont use, including Windows Fax and Scan.

I know enough, where I can go in to the registry and delete orphaned entries without messing up my system.

A program that comes to mind, that can royally mess up the registry, is the registry cleaning tool in Fix-It Utilities. That thing can delete entries it should be deleting when run. I know, cause I tried Fix-It Utilities on XP a number of years ago, and it royally messed up a few things.