Vista - I cant use keyboard or mouse in winsows login

Hi Guys i have a serious problem, 3 days ago i turn on my pc and w8ted till the login screen came up so i tried 2 log in but for some reason my keyboard and mouse didnt wanna movie so i wasnt able 2 log in so i turned the pc off and checked that the usb cables were plugged in and they were but i remved them and plugged it back just in case so i turn my pc back on but it still doesnt work, so i restart my pc and the weird thing is that i can use the keyboard 2 go to bios and stuff so i went 2 safemode but the keyboard and mouse still didnt work and so now i dont know wat to do some 1 please hlp me.

This has been mentioned before. Have a search of this site, this may help.
Try turning on legacy usb support for keyboard and mouse in the bios. If this does not work reinstall the drivers using a ps2 keyboard. You can pick them up for under a fiver.

agreed with roy69..... but don't forget if they are wireless try to pair them again and check the battery's are fully charged

And, just because your mouse is not working doesn't mean the keyboard is not - sometimes your login window can still get commands from the KB - try hitting ALT + TAB and see if the cursor appears in your password box - if it does, then type your password and see if you can get in (hit Enter).