Vista - Motherboard settings

Well i replace/remove my 4GB 2x2GB Kingston 800MHZ DDR2-NON-ECC CL5 DIMM (KVR800D2N5/2G) Kingston KVR800D2N5/2G 2GB DDR2 800 Desktop Memory Kingston 2GB DDR2 800MHz PC2-6400 System Memory KVR800D2N5/2G 240-pin DIMM CL5 Non ECC Unbuffered-Best Computer Online Store Houston Buy Discount Prices Texas-Directron.com
Voltage 1.8

and i insert/install the

Corsair XMS2 Dominator TWIN2X4096-8500C5DF 4GB 2X2GB PC2-8500 DDR2-1066 CL5-5-5-15 240PIN Memory Kit Corsair XMS2 Dominator TWIN2X4096-8500C5DF 4GB 2X2GB PC2-8500 DDR2-1066 CL5-5-5-15 240PIN Memory Kit: TWIN2X4096-8500C5DF
Voltage 2.1

Do i have to change anything in my GA-X38-DS4 motherboard/bios settings?

Hello panais,
If everything in the Bios is set to default, and it's running OK then it should be fine.
If you want to change anything then take a look at the voltage, check on the manufactures site for the recommended voltage and set that in the Bios, sometimes in default mode the memory wont get enough volts.
Unless you are going to overclock your memory,then thats all you need to do.

agreed.....

as long as you set ''optimized defaults'' before uninstalling the old RAM your board will auto detect your new RAM timings & voltages..

though the 1066mhz sticks may default to 800mhz, you'll have to manually alter the frequency in the BIOS...