Vista - cannot download from internet

I have Incredimail and that (plus other programs) now tell me that "Windows
cannot access the specified device path. You may not have the proper
permission to access the item"

The path is
C:\Users\Irene\AppData\Local\Microsoft\Windows\TemporaryInternetFiles\Content\IE56IAZ.... can't see the rest

I am on my own computer and I am the administrator. When I try to follow as
to where this file leads to, it stops at Windows - with no Temporary Internet
Files folder to be seen.

Thanks.