In Windows Vista, even though you are running as an administrator, the
programs you run only run with standard user rights, unless they ask you for
permission or you explicitly give them permission by right-clicking them and
clicking Run As Administrator.
This sounds like the program you are using expects you to be an
administrator, and is not vista-ready because it does not automatically
prompt you for permission.
In order for it to work as expected, you will need to right-click it and
click Run As Administrator.
Vista Support FAQ http://www.jimmah.com/vista/