I recently (06/14/08) updated my machine with a slug of updates, included was a improved version of junk mail removal program. I am running Vista Ultimate 64 and MS Office Professional 2007, using Outlook as my default e-mail application.

The cursor would just hang for two to four minutes (Real minutes, not imagined) with the silly circle spinning if you selected any function. (Like left click the Delete X or Control D) if you tried to click it again the whole screen would fade light gray. Try to exit out and you would get the "Program not Responding" with the three choices of wait, close, or fix it. Well it was not fixing itself. I finally went back into control panel and found KB905866 and removed it

Still did not work, I rebooted the computer and now it "Seems" Normal.... In case it helps someone

Yes it is all normal now, so I expect that was the problem