Vista - Windows Vista running slow to the point of inoperable

Prior to the problem
I activated Microsoft Word and also installed software for a digital camera
(of which compatibility issues may be the problem).
Not all of a sudden, but the next day the computer froze and acted the same
(running extreamly slow) after restarts. THe computer runs fine in safe mode
and I have tried all of the troubleshooting options which I was prompted to
try by Windows Help (System Restore and such).
I am unable to use uninstall for either Moicrosoft Word or "Picture
Package." Is this a function of safe mode?
Is my next option to now reinstall windows?
If so how do I go about this and will I be in danger of losing my liscence
for Microsoft Word since I am unable to unistall it first?
Thanks