Thanks for the help guys. I figured out what the problem is, or at least the main problem. I'm still having leaks I think, coz at the end of the day, my memory doesn't go back down to 30%, which is what it should be at on idle. (I'm currently at 50% with the following open: Firefox, Live Messenger, WinRAR, a couple of explorer windows.
Anyway, the problem was PowerISO virtual drive emulator. I use a lot of iso images to install my files instead of discs. Using Daemon tools instead solved the main issue, tho I still suspect there's still something else going on.
And to answer the questions, I have 3 physical hard drives, no partitions, C: is at 320 GB, D: at 250, and E: at 750 and they are all NTFS drives. I don't use FAT32 formats other than if it's a thumb drive (can't do NTFS on those).
Anyway, thanks again. I guess for the most of it this issue was resolved