Vista - This will solve a big part of the problem in vista.

I think I can post this in all insult.

ReadyBoost do:
ReadyBoost take much of your computer's energy.
It creates problems for the normal driving.
And for the games.
Some are experiencing high load on hard drive as if there running a scanned or index.
The old games (Xp and below) will not tolerate that ReadyBoost start to use energy to get things to run while.

ReadyBoost spend so much energy that you can feel a general improving on your vista after stop.
This will surely solve 60 to 70% of your problems.

Disabled ReadyBoost:
Start -> Control Panel
From the Control Panel home page:
System And Maintenance -> Administrative Tools -> Services (Run as administrator!)

Find the ReadyBoost and Double-click to open the Properties
Click on Stop
Click on the Startup Type column, choose the Disabled option (To never Startup)
Click the OK button

If you need to start ReadyBoost again. Set the Startup Type back to Automatic. Click on Start, or reboot.

This will solve a big part of the problem with running games and other things in Vista. But ReadyBoost can not be used more for things such as USB stick with ReadyBoost.

If you are having problems with readyboost you may also want to have a look Here

It can be recommended to read this article
More user friendly computer.