.Net framework error

When I start up my computer I get a .Net Framework Initalization Error. It has not bothered me up until now. I have downloaded a Garmin Lifetime Map updated and it will not open due to this error. It says I must first install the version of Net Framework V4.0.30319. I have done several downloads of different version nothing helps. I don't know what to do to correct it. PLEASE HELP!!!

Have you tried uninstalling anything to do with .NET 4.0 from Programs and Installed Updates (you'll find bits in both places) and starting over? I'm attaching a pic which gives the KB numbers for all my .NET 4.0 updates which will hopefully help (from Belarc Advisor).

If you used a registry cleaner, optimizer or tune-up utility, see if it has a restore button, as that could be the cause.

Alternately Microsoft support may be able to help, no harm in trying.

I trust this is Vista SP2?

Hi there,

Try uninstalling .Net Framework all versions using a .net framework removal tool.

Download: Microsoft .NET Framework 3.0 Uninstall Tool - Microsoft Download Center - Download Details

Once uninstalled install .net framework 1.1 redistributable Package, .net framework 2.0 redistributable Package, .Net Framwork 3.5 redistributable Package, .Net Framework 4.0 redistributable Package

Hopefully it will work