Vista - Should i install games in program files(x86).

Does anyone know which folder i should be installing games in,they always go in program files(x86),but often wont update because the patch is looking for the game in program files and wont let me change the route?

My full spec:
Intel® Core™2 Quad Extreme QX9650 Processor (3.0GHz, 12MB Cache, 1333MHz) clocked to 4.0 ghz
Genuine Windows Vista™ Ultimate Edition 64 bit with Service Pack 1
Coolermaster Cosmos S Ultra Performance Aluminium Chassis with 1250W PSU
Cooling Pack for COSMOS S Chassis ( 5 red LED 120mm fans)
Performance Pack - OCZ Vendetta Heat pipe quiet cooling, Performance updates, specialist cabling
PCI-Express Mainboard - SLi nForce 780i SLi - Intel Core2Duo/Quad Core - ATX
8GB DDR2 800MHz Memory (4 x 2GB)
2 x 1000GB Serial ATA 2 Hard Drive with 32MB Buffer (2TB Total)
Blu-ray ROM Player Dual layer DVD Writer 24 x CD Writer
Super Format 20x Dual Layer DVD Writer +R/-R/RW/RAM
2x 1GB nVIDIA GeForce 9800GX2 - Dual DVI, HDTV, TV Out
28" Widescreen LCD TFT Digital Display with internal speakers (DVI, 3ms)
Creative Labs Sound Blaster X-Fi Xtreme Gamer Sound Card
Logitech S220 - 2.1 Speakers with Subwoofer
Logitech G11 Gaming Keyboard + MX Revolution Cordless Laser Mouse

I have a map in C: called 'Games' and I put all my games in there, patches find it easily.

I use an second drive to avoid running into such things - typically D:\Program Files\