I have Vista Ultimate x32. I also run Live OneCare constantly when the PC is running.
Lately, when I try to launch a number of different programs, they stop launching and I get a pop-up telling me that XXXXX (name of Program) has stopped working and that Windows is looking for the reason. It never finds anything. Subsequently, I cannot launch the program(s).
I ran a complete scan with Live OneCare and it advise the PC was clean.