Vista - can't delete / move .exe file after it is run in vista 64bit

Vista does have it's quirks, that's for sure, have you tried deleting from an elevated command prompt?
or you could try this, (sometimes it works)
Run notepad.exe
Go "File" "Open"
select the file and hit delete

tries using elevated cmd, get "Access is denied." replay.
tried to remove it from notepad, the same as form explorer - don't work.
the problem for me, I use this computer for programming, and after compiling for the first time since booting the computer, I can't recompile again since it actually deletes the file and compile a new one, but it can't delete and there for can't recompile.
when I try to delete from explorer I get the message "The action can't be completed because the file is open in another program", but I used SysInternals Handle program to find if this file is open, and it is not.
I tried to delete the handle program after running it, just for try, and I can't.
I also tried creating an exe file from application I wrote access it, modify it, and delete it with no problem.
the only file that I can't change or delete is the .exe that I actually run, although the program ended.
I tried disabling the write cash for the disk, it didn't solve the problem.
disabled the antivirus - still no good.
disabled windows defender - still no good.
installed the Sysinternal suit it has more then 40 exe files to same folder, run 16 of them, then tried do delete all.
well all the exe files that I didn't run were deleted ok, the 16 files that I run could not be deleted.

thanks,

Do they resist all changes? Will they cut and paste or accept renaming?

OK, I can rename the file.
I can cut and paste.
it appears I can move the files, but I can't delete them after the rename or move.

but I can only move them within the same disk, if a try to move them from one disk to another, it fails.

thanks

Have you 'Taken Ownership" of your work folders as described in Brink's
tutorial.

Take Ownership of file

Yes I did, made sure i am the owner of the directory and file, before running the file.
remember i can delete the file before i run it. i made sure i have full rights.
after running the .exe, i can't delete it.
but i can change it rights, and take ownership and do all the security changes i want, i can do everything except delete it. i can change its content, i open it with a hex editor and changed its content.

Can you cut and paste to a USB Flash Drive and then yank the sucker?

no I can't. i can't move to a different disk, what it does it just copy to the destination disk, and i receive an error that the file can't be deleted.
i don't have the problem with one file, but with all exe files every where.
after restart all the files are free again as long as i don't start them.
the problem i can't develop i can't restart my computer for every change I make.
and i can't update, for every small update i need to restart since the exe file is locked, and shutting down the application is no good.

Well. I suppose you might try making a new User Account and seeing if the problem isn't there. If it isn't - "migrate" and delete the old account.