Setting changes revert everytime computer restarts

Using Vista 64-bit and the problem is with any changes I make with various settings. When the computer restarts, all of these settings revert back to their initial setting. Mouse settings, IE settings, settings with which program opens up a specific file (e.g. using Notepad to open up an HTML file). I have one administrator account that is being used. At first, this was an inconvenience but it's driving me nuts and haven't found anything online that points me in the right direction regarding this issue.

Any help, ideas or suggestions would be appreciated. Thanks!

Just to see... Log in as administrator, make these changes, reboot, and see what happens.

Yeah, I'm always logged in under my administrator account so the issue is occurring while logged in.