Vista - UAC causes application launch to hang

I have an installation that I built with InstallShield that launches an executable which requires some resource files as well as another program running in the background(MATLAB Component Runtime). When I install this on my Vista 64 machine and then launch the application it just hangs for 5 to 10 minutes. What I mean is that the application begins to launch, as I can see in the Task Manager, but then hangs around 14k. If I just let it keep running eventually 5 or 10 minutes later it will completely launch the app and its interface will pop-up and be active and run normally. If I call the executable(not installed) the program launches fine and everything works fine. Also, if I install the app on my desktop, i.e. not in ProgramFilesFolder, it runs without the delay. The only workaround I could find was to navigate to the installed .exe file and change its Privilege Level to "run program as an adminstrator". I've tried inserting manifests with different execution levels, but that didn't work. Anyone have any clues?