Vista - home page redirected to some antivirus site

Some virus changed my home page to an antivirus site and I used tools to change it back, But when I restarted the IExplorer, it again displayed the antivirus site.

What can I do to fix this up? I do not want to re-install the operating system.Thanks.

What antivirus do you have, and is it a trial or a paid subscription?

Which page? Is it a virus? Is it antivirus XP 2008? You might want to run Search and Destroy.

You might want to try this if you are not wedded to all your current settings in IE. Go to Tools, then Internet Options, then the Advanced tab. You will see a reset button there. This resets IE to its original state. You'll lose your favorite links and so on, but if this is something that has corrupted IE it might take care of it. I had a somewhat similar case of my IE browser suddenly going to a strange site when certain types of search pages were visited first. Antivirus, antispyware found nothing. But when I reset IE the problem vanished. In any case, good luck.

Not necessarily - this sounds more like a virus infestation.

I believe that a virus has changed some file/registry to redirect the home page,
Does some one can tell me how to restore the file/value?
Thanks

Only if we know what registry key you're talking about.

You'll first need to remove the virus you have that is causing this before you can fix the homepage problem.

i ran windows defender and it removed the virus. It did not fix the homepage problem.

If it changes back on a restart then the 'virus' is not gone yet. I highly suggest that you run an online scanner, or else get Malwarebytes.org and run it (the free version allows unlimited on demand scanning, the only thing you get when paying for it (currently) is real time always on scans).