I've tried paperport 12 with Vista X64, it sucks. I can't believe the people at Nuance get away with treating us (customers) the way they do. I called them, asked if it was compatible with Vista (they lied to me on Paperport 11 and said it was, til they couldn't fix it, then they admitted it). They told me Paperport 12 was compatible with 10 also. Well, guess what? NOT!!!!! They said to run a utility to check for corrupt files, all of them were corrupt in 12, but work just fine in 10. I'm sure they have a different viewer in 12, but its not compatible with what they used in 10, and its a pdf file!!!! It may be the other files they put in the folders for thumbnails, or data, not sure, but it craps out when I change to a different folder when it has images in it. If there are no images, its fine. As soon as I pick scan now, paperport 12 bombs out on a windows message that paperport has stopped working. The scanner software works just fine on same machine, and with other software too. Don't be fooled. It may work if its a new installation and you have no files to bring forward, but be forewarned, they don't care this time, won't care on the next update either, they must assume that people buy it for the first time and won't ever upgrade, or just worred about the new sale, leaving us hanging is not their problem.