Welcome Dave,
It appears that you are right, there are conflicts with Vista and Nero. I found this page, in which one poster shows how he solved the problem
CAUTION: Nero 8 problem with Vista - Tech Support Guy Forums
I must admit that I am not familiar with Nero, but I have installed many programs. Some precautions that you may want to take include:
Prior to the install do a maintenance on the computer, defrag, disc cleanup, delete temp folders etc.
I think the most important thing you may try that is not mentioned too often, is to correct any corruption that may be in your OS.
Go to search type cmd (do not hit enter), run as administrator. In cmd type sfc /scannow. This will give you a report of any corruption that is found and try to correct it. If errors are found run the sfc 3 times.
Follow these steps and you will be enjoying Nero.
Take care and good luck
I think that you will be ok