A few key folders are gone from desktop...cannot locate

Hello! This is my first post here...
About aweek ago, when I powerd up my computer, the screen and layout looked like when I first used this for the first time - 5 years ago! My screen saver was gone and replaced with original look when new...my favorites were gone and some folders too. I found these folders elsewhere and stuck them back on desktop...and used the computer again but with the new / old look. When on-line,I started putting back my favorites manually...
Then, 2 days later my background screen was totaly black - no screen saver but all folders were there on black background.. and my favorites were back when on-line. Then today, a few key folders are gone...I tried a few things including doing 2-3 restores, checking "show all folders", etc etc. I did a whole computer scan with no threats.
I searched the named folders with no luck...but could locate some files - when I searched by their file name / label - , but could not open them "cannot open due to "in a location that is not available". One of the found files had this location: C:Users\temp\desktop\images\finalprintversions On my desktop, I had the "finalprintversions" folder inside the "Images" folder...but again still cannot open it and checked the temp folder inside C drive and it was not there.
Any suggestions!!??
Thanks!

I think the hard drive might be going.

However, have you run a full anti-virus scan and a malware scan with Malwarebytes?