Hi chilloh,
This is not a problem per se, nor is it going to cause you any problems other than Vista taking longer to start up. As you use your computer, this folder will be re-populated with the files it requires. Some people who work with sensitive data consider this to be a security issue and so, like it is possible to do with the paging file, arrange for this folder to be emptied when they log off, usually through a script that runs at that time.