My computer was infected with Vista Guardian 2010 two days ago. I first ran a full scan using McAfee but didn't detect anything. Following a friend's advice, I then ran Windows Update on the system. After restarting, I lost my desktop, only a small window saying "Personalizing the personal setting of your Internet Explorer" and it stayed there for ever. I managed to get online through Task Manager by hiting ctrl+alt+del. Then I downloaded Microsoft Security Essential and it found two malwares. I clicked "Remove Now" to the first one and my desktop came back. So when the second message prompted me to "Restart Now", I restared my computer while the scanning was still running. After restarting, everything was fine except a bit slower than before. But when I tried to open any .exe file (like IE browser, Firefox browser, MS Security Essential), none of them would open. The system keeps asking me which software I want to use to open the file, and still wouldn't open. I cannot open any browsers and cannot get online now. What should I do? (I tried in Safemode, and didn't work either). Thanks a lot!